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2024-12-18 16:12 The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD models - Nature.com
2024-07-01 09:39 MEK inhibitors: a promising targeted therapy for cardiovascular disease - Frontiers
2024-09-05 07:06 Echinatin alleviates sepsis severity through modulation of the NF-κB and MEK/ERK signaling pathways - ScienceDirect.com
2024-07-30 04:07 MEK’s shadow in European Parliament - Responsible Statecraft
2024-06-26 07:00 MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells - Science
2024-12-13 11:30 Extension for the Project on the Sámi Collection at MEK until November 2025 - Staatliche Museen zu Berlin
2024-12-09 17:03 Early December Scenario: MEK Prices Takes Pressure of Low Demand and Global Supply Excess - ChemAnalyst
2024-09-09 07:00 Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage - Nature.com
2024-05-01 07:00 Effect of NFX-179 MEK inhibitor on cutaneous neurofibromas in persons with neurofibromatosis type 1 - Science

2024-10-22 07:00 MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB - Nature.com
2024-06-24 07:00 MEK-inhibitor treatment reduces the induction of regulatory T cells in mice after influenza A virus infection - Frontiers
2024-09-22 07:00 MEK Menopause Special Focus Day on 22 September 2024: It’s far from over! - Staatliche Museen zu Berlin
2024-05-15 07:00 Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies - Nature.com
2024-02-22 08:00 The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction - Nature.com
2024-04-10 07:00 CDK4/6 inhibition sensitizes MEK inhibition by inhibiting cell cycle and proliferation in pancreatic ductal adenocarcinoma | Scientific Reports - Nature.com
2024-02-26 08:00 Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRAS - Nature.com
2024-04-06 07:00 The prognostic value of MEK pathway–associated estrogen receptor signaling activity for female cancers - Nature.com
2024-04-25 07:00 TMEM9 promotes lung adenocarcinoma progression via activating the MEK/ERK/STAT3 pathway to induce VEGF expression - Nature.com
2024-01-22 08:00 A MEK inhibitor arrests the cell cycle of human conjunctival fibroblasts and improves the outcome of glaucoma filtration surgery - Nature.com

2024-02-29 08:00 Cysteine protease inhibitor 1 promotes metastasis by mediating an oxidative phosphorylation/MEK/ERK axis in esophageal squamous carcinoma cancer - Nature.com
2024-12-22 13:52 A Test of Endurance: Cyber Assaults and the Iranian Resistance’s Marathon Toward Change - National Council of Resistance of Iran (NCRI)
2024-01-21 08:00 Dual inhibition of MEK and PI3Kβ/δ–a potential therapeutic strategy in PTEN-wild-type docetaxel-resistant metastatic prostate cancer - Frontiers
2024-01-18 08:00 Rapid diurnal variation of serous retinal detachment during BRAF and MEK inhibitor treatment: A case series - Wiley Online Library
2024-08-23 00:42 The Küppers Collection at MEK - Staatliche Museen zu Berlin
2022-04-07 07:00 MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment - Nature.com
2023-07-12 07:00 BRAF–MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas - nejm.org
2023-04-06 07:00 MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ - Nature.com
2019-11-27 20:23 Catalytic behavior and reaction routes of MEK oxidation over Pd/ZSM-5 and Pd–Ce/ZSM-5 catalysts - ScienceDirect.com
2012-06-04 07:00 Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma - nejm.org

2023-03-24 07:00 Ocular Toxicities of MEK Inhibitors in Patients With Cancer: A Systematic Review and Meta-analysis - Cancer Network
2020-12-17 08:00 MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes - Nature.com
2022-07-16 07:00 Iran blacklists US officials for supporting ‘terrorist’ group MEK - Al Jazeera English
2014-09-29 07:00 Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma - nejm.org
2018-10-19 07:00 Targeting MEK in vemurafenib-resistant hairy cell leukemia - Nature.com
2015-06-05 07:00 MEK inhibitors: a new class of chemotherapeutic agents with ocular toxicity - Nature.com
2023-11-02 07:00 Live-cell target engagement of allosteric MEKi on MEK–RAF/KSR–14-3-3 complexes - Nature.com
2021-03-30 07:00 PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK - ScienceDirect.com
2019-12-09 08:00 MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia - Nature.com
2022-07-14 07:00 Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression - Nature.com

2012-09-29 07:00 US removes Iran group MEK from terror list - BBC.com
2018-11-09 08:00 Terrorists, cultists – or champions of Iranian democracy? The wild wild story of the MEK - The Guardian
2020-09-08 07:00 MEK Inhibitors for the Treatment of Low-Grade Serous Ovarian Cancer: Expanding Therapeutic Options for a Rare Ovarian Cancer Subtype | Journal of Clinical Oncology - ASCO Journals
2018-11-06 08:00 BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association - ScienceDirect.com
2019-05-16 07:00 MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer - Nature.com
2023-10-13 07:00 MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling - Nature.com
2022-11-23 08:00 MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression - Nature.com
2012-09-21 07:00 MEK decision: multimillion-dollar campaign led to removal from terror list - The Guardian
2024-10-26 19:06 A visit to the MEK camp in Albania, where Iran's fighting opponents "are not even allowed to think about sex" - Telegrafi
2023-11-13 23:17 Bruceine A: Suppressing metastasis via MEK/ERK pathway and invoking mitochondrial apoptosis in triple-negative breast cancer - ScienceDirect.com

2013-09-26 07:00 Concurrent MEK2 Mutation and BRAF Amplification Confer Resistance to BRAF and MEK Inhibitors in Melanoma - ScienceDirect.com
2019-08-21 07:00 MEK Inhibitor Mechanism of Action, Side Effects, and Uses - News-Medical.Net
2019-03-13 07:00 Efficacy of MEK inhibition in patients with histiocytic neoplasms - Nature.com
2014-07-28 07:00 Mujahadeen-e-Khalq (MEK) - Council on Foreign Relations
2018-03-29 07:00 MEK’s violent past looms over US lobby for regime change in Iran - Al Jazeera English
2017-09-19 07:00 Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer - Nature.com
2020-05-01 07:00 Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy - Nature.com
2017-12-31 14:20 Murine Ksr interacts with MEK and inhibits Ras-induced transformation - ScienceDirect.com
2020-09-14 07:00 Structural basis for the action of the drug trametinib at KSR-bound MEK - Nature.com
2012-09-29 07:00 Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations - nejm.org

2020-10-05 07:00 Continuous versus intermittent BRAF and MEK inhibition in patients with BRAF -mutated melanoma: a randomized phase 2 trial - Nature.com
2021-10-07 07:00 Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling - Nature.com
2018-07-02 07:00 Who is the Iranian group targeted by bombers and beloved of Trump allies? - The Guardian
2022-07-13 07:00 Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer - Nature.com
2016-02-26 08:00 MEK inhibitor, TAK-733 reduces proliferation, affects cell cycle and apoptosis, and synergizes with other targeted therapies in multiple myeloma - Nature.com
2019-03-04 08:00 Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers - Nature.com
2023-05-25 07:00 Histological transformation to gliosarcoma with combined BRAF/MEK inhibition in BRAF V600E mutated glioblastoma - Nature.com
2019-11-18 08:00 Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases - Nature.com
2019-03-04 08:00 MEK nuclear localization promotes YAP stability via sequestering β-TrCP in KRAS mutant cancer cells - Nature.com
2009-09-02 07:00 Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras - Nature.com

2023-01-26 08:00 Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial | Nature Medicine - Nature.com
2021-12-21 08:00 MEK inhibition exerts temporal and myeloid cell-specific effects in the pathogenesis of neurofibromatosis type 1 arteriopathy - Nature.com
2022-04-25 07:00 MEK Inhibition Is Now a Standard of Care in Recurrent Low-Grade Serous Ovarian Cancer: What Next? - The ASCO Post
2019-07-26 07:00 Global view of the RAF-MEK-ERK module and its immediate downstream effectors - Nature.com
2021-07-24 07:00 Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRAF -mutant melanoma - Nature.com
2021-02-12 08:00 Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor - Nature.com
2023-10-30 07:00 Former MEK leader Massoud Rajavi died under US guard, say Iran media - Al Jazeera English
2020-05-04 07:00 The limitations of targeting MEK signalling in Glioblastoma therapy - Nature.com
2019-02-25 08:00 MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer - Nature.com
2016-05-25 07:00 Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells - Nature.com

2020-06-16 07:00 Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers - ScienceDirect.com
2016-12-13 08:00 Yes, We Do Know the MEK Has a Terrorist Past - POLITICO
2023-01-26 08:00 Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors | Cell Death & Disease - Nature.com
2021-09-01 01:33 Targeting enhancer reprogramming to mitigate MEK inhibitor resistance in preclinical models of advanced ovarian cancer - JCI
2019-07-01 07:00 ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor - Nature.com
2018-09-07 07:00 RETRACTED ARTICLE: MEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells - Nature.com
2018-02-12 08:00 MEK drives BRAF activation through allosteric control of KSR proteins - Nature.com
2014-05-20 07:00 The clinical development of MEK inhibitors - Nature.com
2023-11-16 19:12 SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status - pnas.org
2012-04-17 07:00 Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: selumetinib in patients with cholangiocarcinoma - Nature.com

2013-07-12 07:00 MEK drives cyclin D1 hyperelevation during geroconversion - Cell Death & Differentiation - Nature.com
2019-09-20 07:00 Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors - Nature.com
2015-03-18 07:00 Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAFV600E melanoma - Science
2023-01-30 08:00 The incidence and characterization of weight gain associated with MEK inhibitors in pediatric patients - Wiley Online Library
2005-11-06 08:00 BRAF mutation predicts sensitivity to MEK inhibition - Nature.com
2018-08-20 07:00 Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells - Nature.com
2022-01-24 08:00 Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations - Nature.com
2012-04-09 07:00 Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973) - ACS Publications
2019-06-10 07:00 SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers - Nature.com
2016-10-25 07:00 MEK Inhibitors Reverse Growth of Embryonal Brain Tumors Derived from Oligoneural Precursor Cells - ScienceDirect.com

2017-04-03 07:00 TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function - Nature.com

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